Ein Blick über den disziplinären Tellerrand. Über die Potenziale eines kommunikationswissenschaftlichen Medienverständnisses für die geschichtsdidaktische Mediendiskussion im digitalen Wandel

Astrid Schwabe plädiert in ihrem Beitrag „Ein Blick über den disziplinären Tellerrand“ für eine neue Begriffsdefinition des Medienbegriffs im geschichtsdidaktischen Zusammenhang. Anhand von Überlegungen von Lutz Goertz zeigt sie die Schwierigkeiten und Herausforderungen auf, die der digitale Wandel an ein integratives Medienkonzept stellt. Sie stellt einen Fokuswechsel vom Medium hin zur Medienanwendung fest und somit die Wichtigkeit der Auseinandersetzung mit den neuen Instrumenten (wie Twitter etc.) und deren Nutzern

Selection of event tickets for bundling in sports and entertainment industry

Due to copyright restrictions, the access to the full text of this article is only available via subscription.Most sports and entertainment firms offer season tickets first, and they allow purchasing single tickets at a later date. Basic decision problems within this context are the determination of optimal time at which switch from bundled tickets to single tickets should occur and the decision of which event tickets to include into the bundle. In this paper we focused on the second decision problem. For a given schedule of events, where ticket demands follow a Poisson Process, the tickets of a certain number of events are bundled and a discount is applied to the prices of these bundled tickets, with the aim of increasing total revenue. We find increase and decrease patterns in total revenue as the time slots of bundled events vary. With the help of these patterns, we develop a heuristic approach that creates easy-to-use business rules for the selection of profitable bundles for a given schedule

Schlüsselbegriffe der Public History

Der Band stellt Schlüsselbegriffe der Public History vor und erschließt diese über die wichtigsten Themenfelder und zentrale Forschungsperspektiven. Er richtet sich an Studierende, Lehrende und Praktiker:innen, die sich mit Geschichte in der Öffentlichkeit befassen und bietet Zugänge zur theoretischen Fundierung der Public History als Teil der historischen Kulturwissenschaften an

Hepatic sinusoidal obstruction syndrome and short-term application of 6-thioguanine in pediatric acute lymphoblastic leukemia

Long-term treatment with 6-thioguanine (6-TG) for pediatric acute lymphoblastic leukemia (ALL) is associated with high rates of hepatic sinusoidal obstruction syndrome (SOS). Nevertheless, current treatment continues to use short-term applications of 6-TG with only sparse information on toxicity. 6-TG is metabolized by thiopurine methyltransferase (TPMT) which underlies clinically relevant genetic polymorphism. We analyzed the association between hepatic SOS reported as a serious adverse event (SAE) and short-term 6-TG application in 3983 pediatric ALL patients treated on trial AIEOP-BFM ALL 2000 (derivation cohort) and defined the role of TPMT genotype in this relationship. We identified 17 patients (0.43%) with hepatic SOS, 13 of which with short-term exposure to 6-TG (P < 0.0001). Eight of the 13 patients were heterozygous for low-activity TPMT variants, resulting in a 22.4-fold (95% confidence interval 7.1–70.7; P ≤ 0.0001) increased risk of hepatic SOS for heterozygotes in comparison to TPMT wild-type patients. Results were supported by independent replication analysis. All patients with hepatic SOS after short-term 6-TG recovered and did not demonstrate residual symptoms. Thus, hepatic SOS is associated with short-term exposure to 6-TG during treatment of pediatric ALL and SOS risk is increased for patients with low-activity TPMT genotypes